Liverpool can make to the top of the Premier League table on Saturday for the first time this season.
Jurgen Klopp's side only need a point to climb above local rivals Everton and claim top spot going into Sunday.
However, they'll be up against a West Ham side that gave a good account of themselves against Manchester City last weekend.
Liverpool's defensive worried intensified on Tuesday night when stand-in central defender Fabinho limped off.
Despite scans showing the injury isn't as bad as first feared, he's still set to miss Saturday's match, and may not appear again until after November's international break.
Klopp may have to field an inexperienced defender for the visit of West Ham, or move another of his midfielders back to fill the void.
Anfield is the scene of the last of Saturday’s three Premier League fixtures, which starts at 5.30pm.
Manchester City and Chelsea play earlier in the day, going to Sheffield United at 12.30pm and Burnley at 3pm respectively.
Meanwhile Manchester United host Arsenal on Sunday at 4.30pm, while Everton go to Newcastle for the day’s 2pm kick-off.
Sky Sports ' Main Event and Premier League channels will be showing Saturday's clash at Anfield, with coverage starting on both channels at 5pm.
Fans with Sky Sports subscriptions can stream the game through Sky Go or Now TV apps.
Sky Sports will also be showing Newcastle vs Everton and Manchester United vs Arsenal on Sunday afternoon.
Liverpool are just one game away from equalling their longest ever unbeaten home run set between 1978 and 1980, a staggering 63 successive league matches.
But this could be the toughest test yet in that long sequence of home rule.
No Virgil van Dijk, no Fabinho, Joel Matip struggling – and facing a West Ham side unbeaten in four matches which include clashes with Manchester City and Spurs.
Liverpool are understandably odds on at 2/5 with thepools.com, but West Ham have to be worth a tickle at 13/2 as does the draw at 17/4.
The Hammers have scored five goals after the 80th minute across their last four PL matches and the second half to be West Ham's highest scoring half is 2/1.
While Over 3.5 goals in the fixture is Evens – and goals have been a consistent theme for The Hammers – their four away matches have averaged 4.25 total goals, and in this fixture with total goals output in their last four visits to Anfield close to a 4.5 average.
Diogo Jota has scored in back-to-back matches and is 9/2 to score first, while Michael Antonio, who has scored two in West Ham’s last three, and has two in the last five clashes with Liverpool, is 15/2.
Odds are courtesy of thepools.com and subject to change.
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