Manchester United midfielder Paul Pogba has tested positive for coronavirus.
He has been left out of France's squad with Eduardo Camavinga earning a call-up in his place.
Tottenham's Tanguy Ndombele has also tested positive, report L'Equipe.
Les Bleus take on Sweden and Croatia in the Nations League on their return to action, but will be without the Premier League duo.
Pogba's United teammate, Anthony Martial, is in the squad.
France boss Didier Deschamps said: "I had to make a last-minute change to this list, because Paul Pogba was planned to be in this list but unfortunately for him, he took a test (for COVID-19) yesterday which turned out to be positive today, so at the last minute he was replaced by Eduardo Camavinga."
A statement from United said: “Paul has been replaced in the French squad after testing positive for Covid-19. Everybody at United wishes him a speedy recovery ahead of the new season.”
The news comes after several Chelsea stars were forced into isolation after a breakout of Covid-19 derailed their pre-season plans.
Mason Mount, Tammy Abraham, Christian Pulisic and Fikayo Tomori are among those in isolation, having all recently holidayed in Mykonos.
Blues boss Frank Lampard has begun pre-season at Cobham, but will need to wait to be joined by those players in quarantine.
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Abraham and Mount were both named by Gareth Southgate in the England squad for upcoming Nations League games against Iceland and Denmark.
Other clubs have also been hit with positive tests since the end of the season.
Sheffield United, West Ham and Brighton were among 12 different clubs to record a total of 14 positive tests between them.
Liverpool are also believed to have had one member of their travelling party carrying the virus after testing shortly after landing in Austria.
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