And then there was one.
Liverpool went into their title defence, with arguably, the strongest back-four in the entire Premier League.
Coming off the back of winning 99 points in 2019/20, Jurgen Klopp's men will be hoping for something similar this time around.
The sale of Dejan Lovren had sparked some fears about a lack of depth, but even the most pessimistic Liverpool fan couldn’t have expected the injury crisis now facing the club.
Firstly it was Virgil van Dijk, with the Dutchman’s season likely ended with a serious knee injury.
Then after the 1-1 draw with Manchester City on Sunday, Trent Alexander-Arnold suffered a calf injury, one that could keep him out for an extended period of time.
And then to make matters worse, Joe Gomez has reportedly suffered a serious injury whilst on international duty with England.
It means Andy Robertson is the only member of that vaunted back-four still at full fitness.
But the Scotland skipper, who will hope to guide his country to Euro 2020 this week, has admitted that the idea of playing different formations is an appealing one.
Against Pep Guardiola’s side, Klopp opted to start four attackers, as the debate about Diogo Jota and Roberto Firmino rumbles on.
"We had four attackers on the pitch, Diogo's form speaks for itself and Bobby is so important for the team as are the two wingers,” he said, after the draw with City.
"The manager made the decision and we worked on it for the past couple of days and hoped that in the first couple of minutes we could surprise Man City.
"It's another formation we can play with bringing in Diogo and then Shaq [Xherdan Shaqiri] came on.
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"It's a formation that we can use and it's important that's how we adapt as a team, by playing more formations and trying to surprise other teams."
That willingness to adapt could prove vital in coming weeks, particularly with Klopp hinting that Robertson could shift over to the centre of defence.
Last month, the Reds boss named the former Hull City man as an option to cover for Van Dijk & Co: “We have still, obviously, other options like Hendo or Gini or James – or Robbo can play centre-half as well. They are all not smaller than Mascherano, for example, and he played pretty well in that position.”
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