Manchester City are looking for their first Premier League win since their opening match. Arsenal, on the hand, are targeting a fourth victory from their opening five games.
City striker Sergio Aguero is back in training but the clash against the Gunners will come too soon.
Kevin De Bruyne and Raheem Sterling are both doubts after picking up knocks during the international break.
Arsenal could give deadline day signing Thomas Partey his debut against City.
The Gunners will hope to have Kieran Tierney available after having to self-isolated due to a Scotland team-mate testing positive for COVID-19.
The Premier League fixture kicks off at 5.30pm BST on Saturday, October 17.
Live coverage of the match will be shown on Sky Sports Main Event and Sky Sports Premier League.
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Existing customers can live stream the game via the Sky Go app.
Those without a subscription can still watch the action by purchasing a Sky Sports pass through NOW TV.
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Former Premier League striker Michael Owen told Bet Victor: “The glamour fixture on Saturday is at the Etihad.
“Arsenal make the visit to Manchester with their tails up.
“It’s been a pretty solid start from the Gunners, and they will go here with high hopes of taking something.
“City simply need to pick up, and back on home soil I can see Pep rallying his troops to claim the points.”
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